Our Research

Our group investigates regulation of immune responses by human tissue resident dendritic cells using a comprehensive systems immunology approach: in silico modelling of transcriptomic networks leading to identification and perturbation of molecular switches.

Here you can find updates on our latest research and publications:

Genomic programming of IRF4-expressing human Langerhans cells (2020)
https://www.nature.com/articles/s41467-019-14125-x

Resolving cellular systems by ultra-sensitive and economical single-cell transcriptome filtering (2019)
https://www.biorxiv.org/content/10.1101/800631v2

Machine learning applied to atopic dermatitis transcriptome reveals distinct therapy-dependent modification of the keratinocyte immunophenotype (2019)
https://www.medrxiv.org/content/10.1101/2019.12.14.19014977v1

Single cell transcriptomic analysis identifies Langerhans cells immunocompetency is critical for IDO1- dependent ability to induce tolerogenic T cells. (2019)
https://www.biorxiv.org/content/10.1101/2019.12.20.884130v1.full

A graphical and computational modeling platform for biological pathways (2018)
https://www.nature.com/articles/nprot.2017.144

Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation (2017)
https://www.nature.com/articles/s41598-017-00651-5

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